PLTsoft is pleased to announce the release of PLT Tools version 2.1, software tools to facilitate the conduct of NONMEM* analyses on either the Windows, Linux, or OS X platforms. PLT Tools has undergone many enhancements since the initial release in 2008.

PLT Tools is a suite of tools that accomplish the following:

• Project Controller: Using a graphical interface (image appears below), run NONMEM, automatically create numerous files containing NONMEM outputs and tables, create extensive graphics, and perform various statistical analyses.  Folders are created automatically, all source documents are archived, and all files are time-stamped, facilitating Part 11 compliance.  Tables created by NONMEM are copied, then reformatted so that they open automatically in Excel. A unique feature is a 1-2 page summary ("Brief Summary") showing the objective function, the number of significant digits, final estimates (and standard errors if available) for thetas, omegas, and sigmas and diagnostics of NONMEM boundary conditions. Examples can be downloaded. Informative warning/error messages supplement (obscure) messages from NONMEM. The Project Controller enables the user to run NONMEM in the normal mode (estimation or simulation) or to run a Visual Predictive Check, a Bootstrap analysis, a Likelihood Profile, or a Jackknife analysis. In addition, a window appears on the user's desktop to display real-time updates of the objective function and parameters (image appears below).

• Compare Runs: Compare one or more pairs of runs:

The output is a text file that can be inserted as an appendix in a study report.  In addition, a comma-delimited table summarizes differences between runs, objective functions and the change between models, the P value for the likelihood ratio test, the number of non-fixed thetas, omegas, and sigmas in each model, and comments entered by the user.

• Create Archive: With one click, bundle together the outputs of one run or multiple runs into a time-stamped archive. Ideal for transfer or archiving of a ongoing or completed project.

These tools are facilitated by the following:
• Graphics Editor: Using a graphical interface, select options for the creation of graphics.  No knowledge of S-Plus/R code is required.
• Run Listing Editor: During an analysis, timestamps for all runs are tabulated.  Using pull-down menus, select the runs to be used by the Compare Runs and Create Archive Tools.
• Control Stream Editor: The user can edit a control stream directly from PLT Tools.
• Control Stream Library: The user can access a library of control streams, then edit the control streams for their own use.

PLT Tools is available via download from this website. The free version provides nearly all features (see Licensing for details). Licensing unlocks the remaining features.

* NONMEM is a registered trademark of the Regents of the University of California. Licenses for NONMEM can be obtained from Icon Development Solutions.

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