Dennis Fisher and Steven Shafer are both anesthesiologists by training.  Dennis spent 20 years at UCSF, working closely with Lewis Sheiner and Stuart Beal, the founders of NONMEM.  He now consults full-time in the area of pharmacokinetics, pharmacodynamics, and pharmacometrics; his consulting firm is "P Less Than".  Steve spent most his academic career at Stanford University, recently moving to Columbia University, and also worked closely with Sheiner and Beal.  He is presently Editor-in-Chief of Anesthesia and Analgesia.

In 2003, Steve started teaching a NONMEM course.  In 2005, Dennis joined the course, now entitled "Fisher / Shafer NONMEM Course", taught 2-3 times / year in the US and abroad.  As part of that course, Dennis provided extensive graphics scripts to the enrollees and Steve distributed an operating sysem script "go" that runs NONMEM, creates graphics, and manages files and folders ("go" is based on a Unix script "doit" developed by Dennis).

In 2006, we decided that the NONMEM user community would benefit from a graphical user interface to manage the entire NONMEM analysis process.  PLT Tools is the amalgamation of these various scripts into a graphical user interface (GUI).  We are pleased to offer PLT Tools as the first comprehensive software tool to facilitate NONMEM analyses.

Acknowledgements: Alison Boeckmann, the programmer for the NONMEM Project Group for most of its existence, has been a remarkable resource to both of us.  The "Brief Summary" provided with each NONMEM run and the "Compare Runs" tool would probably not exist without Alison's development of the "nmsee" software.  Michael Diehr, Xochi Media, is responsible for developing the graphical user interface.  Finally, Zachary Fisher and Jeremy Fisher have provided invaluable help in web and GUI design.

Webmaster