Appendix. Brief summaries of each NONMEM run. _______________________________________________________________________________________________ SUMMARY OF NONMEM RUN 080304-144718 ______________________________ Minimum value of the objective function: 1773.038 Number of significant digits: 3.2 _______________________________________________________________________________________________ Comments extracted from control file: 1-compartment base model _______________________________________________________________________________________________ Final estimates for THETAs are: THETA# Final Estimate Standard Error Coeff. of Var. Comment 1 4.43 0.335 0.0756 2 1.11 0.0651 0.0586 _______________________________________________________________________________________________ The following OMEGAs were fixed to zero (unused): 3,4 ______________________________ The following OMEGAs are block: OMEGA# Variance sqrt(Variance) Covariance Correlation Comment 1 0.113 0.3362 2 0.0435 0.2086 1/2 -- -- -0.0419 -0.598 _______________________________________________________________________________________________ The following SIGMAs are diagonal: SIGMA# Variance sqrt(Variance) Comment 1 0.0576 0.24 2 24.4 4.9396 _______________PAGEBREAK________________ _______________________________________________________________________________________________ SUMMARY OF NONMEM RUN 080304-145904 ______________________________ Minimum value of the objective function: 1415.324 Number of significant digits: 3.1 _______________________________________________________________________________________________ Comments extracted from control file: 2-compartment base model _______________________________________________________________________________________________ Final estimates for THETAs are: THETA# Final Estimate Comment 1 3.57 2 1.02 3 0.873 4 6.17 Standard errors were not reported. _______________________________________________________________________________________________ The following OMEGAs are block: OMEGA# Variance sqrt(Variance) Covariance Correlation Comment 1 0.137 0.3701 2 0.0451 0.2124 1/2 -- -- -0.0483 -0.614 3 0.0972 0.3118 1/3 -- -- 0.0377 0.327 2/3 -- -- -0.0135 -0.204 4 0.273 0.5225 1/4 -- -- -0.0487 -0.252 2/4 -- -- 0.0709 0.639 3/4 -- -- 0.102 0.626 _______________________________________________________________________________________________ The following SIGMAs are diagonal: SIGMA# Variance sqrt(Variance) Comment 1 0.0557 0.236 2 0.00001 0.0032 & _______________________________________________________________________________________________ NONMEM reported a BOUNDARY condition; typically, this prevents calculation of standard errors. None of the THETA terms are at the boundaries The following SIGMA term(s) was < 0.0001 of the initial estimate, probably triggering a boundary condition: 2 _______________________________________________________________________________________________ Explanation of Comments & One or more SIGMA term is < 0.0001 of the initial estimate _______________PAGEBREAK________________