Appendix.  Run-by-run comparison


SUMMARY OF NEW MODEL (080304-144718)
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Model 080304-144718 
	Objective function:		 1773.038 
	Number of significant digits:	 3.2
Comments in control stream for new model:
 1-compartment base model
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COMPARISON OF NEW MODEL (080304-145904) AND OLD MODEL (080304-144718)
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Model 080304-145904 
	Objective function:		 1415.324 
	Number of significant digits:	 3.1
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Model 080304-144718 
	Objective function:		 1773.038 
	Number of significant digits:	 3.2
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Difference between objective functions (old model - new model):	 357.714
Additional parameters in new model:				 2
P value for likelihood ratio test:				 < 0.00005
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Comments in control stream for new model:
 2-compartment base model
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Comments in control stream for old model:
 1-compartment base model
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Text in control stream that appears in new model but not in old model:
    $SUBROUTINES ADVAN3
           CLRA  = THETA(3) * EXP(ETA(3))
           V2    = THETA(4) * EXP(ETA(4))
           K12   = CLRA / V1
           K21   = CLRA / V2
           (0  1          ) ; theta(3) is CLdistribution
           (0  1          ) ; theta(4) is V2
    $OMEGA BLOCK(4)
    ;       ETA1 ETA2 ETA3 ETA4
           (0.1  0.1  0.3     ) ; ETA3 applies to CLdistribution
           (0.1  0.1  0.1  0.3) ; EPS4 applies to V2
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Text in control stream that appears in old model but not in new model:
    $SUBROUTINES ADVAN1
           CLRA  = 0
           V2    = 1
    $OMEGA BLOCK(2)
    ;       ETA1 ETA2
    $OMEGA (0 FIX             ) ; ETA3 applies to CLdist - not used
           (0 FIX             ) ; ETA4 applied to V2 - not used
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