As users are well aware, installation of NONMEM can be difficult. Historically, most problems related to the interaction between the Fortran compiler and the script used to install NONMEM. In recent years, open-source Fortran compilers (G77 and G95) have become available and these compilers usually allow seamless installation of NONMEM on most platforms using Globomax's NONMEM installer.

Installation of PLT Tools on Windows platforms has been difficult in certain situations. The most common of these is that the installer for PLT Tools selects a flawed or outdated copy of nmfe6.bat. When PLT Tools executes NONMEM, it calls this flawed copy of nmfe6.dat, then fails to run NONMEM properly.

If you are unable to run PLT Tools, we recommend the following:

1. Read the messages in the OUTPUT window in the Project Controller. Often, an explanation is provided.

2. If the messages don't clarify the source of the problem (or if the message "NONMEM has not started" appears repeatedly), click "Copy", then paste the contents of the clipboard into an email. Attach a copy of \PLTTools\nmfe6.bat (you probably need to change the extension to .txt in order to bypass firewalls). Then email both to support@PLTsoft.com; the Subject line should read "PLT Tools Installation Problem". We will contact you shortly with recommendations.

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