PLT Tools is a suite of tools that facilitates the conduct of NONMEM* analyses and does the following:

Run NONMEM from a graphical interface

• Run NONMEM's estimation and/or simulation steps in the usual manner.
• Run a Covariate Search, Visual Predictive Check, Bootstrap analysis, Likelihood Profile, or Jackknife analysis.
• Informative warning/error messages supplement (obscure) messages from NONMEM.

Create high-quality graphics

• Using a graphical interface, select options for the creation of graphics.
• Graphics are created in PDF and JPEG formats by R; no knowledge of R required.

File NONMEM outputs automatically

• Folders are created automatically in a standardized file structure.
• All files created by NONMEM (outputs, tables) are archived.
• Tables created by NONMEM are copied, then reformatted so that they open automatically in Excel (csv format).
• A 1-2 page ("Brief Summary") is created: it shows the objective function, the # of significant digits, final estimates (and standard errors, if available) for THETAS, OMEGAS, and SIGMAS and diagnostics of NONMEM boundary conditions.
• All files are time-stamped, facilitating Part 11 compliance.

Perform statistics

• A GLM analysis, similar to a GAM, is performed.
• Population and post hoc halflives are calculated for compartmental models.
• Post hoc parameters are summarized (mean / SD / median / minimum / maximum) in a table.

Edit Control Streams without leaving PLT Tools

• The user can edit a Control Stream using PLT Tools's built-in editor.
• Or, access your preferred editor from PLT Tools.

Model diagnostics using xpose

• Access xpose graphics and tables from pull-down menus.

Summarize runs and prepare a report (RTF format)

• Compare pairs of runs: change in the objective function, P value for the likelihood ratio test.
• Compare pairs of Control Streams line-by-line.
• Assemble tables summarizing data, covariates, NONMEM runs, population and post hoci parameters, etc.
• Assemble a table summarizing differences between runs, objective functions and the change between models, P value for the likelihood ratio test, the number of THETAS, OMEGAS, and SIGMAs in each model, and comments entered by the user.
• Create a Word document that includes these tables, selected NONMEM outputs and graphics (download example).

Create an archive of a project

• With one click, bundle together files (NONMEM outputs and tables, graphics, etc.) for one or more runs into a time-stamped archive.
• Ideal for transfer or archiving of an ongoing or completed project.

Select runs to be used by the "Prepare a Report" and Archive Manager tools

• During an analysis, timestamps for all runs are tabulated.
• Select runs to be used by the "Prepare a Report" and Archive Manager Tools.